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Allen and Doisy (1923)found that an alcoholic extract of ovaries wascapable of producing estrus and devised a simplebioassay method. Minuteventilation and mean airway pressure were higherand end-expiratory volume was lower duringPSV + VG compared to SIMV. This unique positionin the circulatory system aids the liver in its normal functions,which include (i) carbohydrate storage and metabolism; (ii)metabolism of hormones, endogenous wastes, and foreignchemicals; (iii) synthesis of blood proteins; (iv) ureaformation; (v) metabolism of fats; and (vi) bile formation.When drugs or chemicals are absorbed from the gastrointes-tinal tract, virtually all of the absorbed dose must passthrough the liver before being distributed through the blood-stream to the rest of the body. (2010) Effects of memory train-ing on cortical thickness in the elderly. 226) argue that it is this “first step of asking well-built questions” that is of primary importance in EBP, “because everything else hingesupon it.” Posing a focused and answerable question allows the clinician to narrow thesearch for evidence and to perform a better assessment of the feasibility and relevance offindings.

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