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Still, successful application of NGS-based gene identi? cationstudies will continuously improve thanks to advancements in both technologiesand bioinformatics strategies and will lead to the identi?cation of the associatedgenes for almost all described 7,000 rare disorders in the next couple of years.The question remains how the ?eld of molecular and human genetics will moveforward after all these genes have been identi?ed? We have no doubt that manynew questions will arise concerning the genetics of rare diseases, opening newareas of genetic investigations such as: What are the genetic modi?ers of pheno-typic variability in monogenic diseases? How frequent are digenic and poly-genic inheritance in rare disorders? What is the impact of epigenetic variationon phenotypes? What is the exact role of somatic mosaicism? All these ques-tions will be addressed and we expect novel fascinating ?ndings to underline thecomplexity of genetic inheritance even in monogenic and rare disorders.Moreover, we will spend much more time elucidating the molecular pathogen-esis of rare diseases using detailed functional studies in vitro and in vivo.

(2006) Educa-tion and rates of cognitive decline in incident Alzheimer’s dis-ease.

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Concato?J,?Peduzzi?P,?Holford?TR,?Feinstein?AR.?Importance?of?events?per?independent?variable in proportional hazards analysis. In some cheap Keppra online there may be a sig-nificant disruption in sleep onset or the ability to sit stillfor a long car ride or movie. Once the patient is on a stable dosing, serialfollow up every 3–6 months with a geriatric neurologistis highly recommended for continued patient safety

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A meta-analysis of CPAP vs.theophylline for apnea of prematurity was pub-lished in 2001 by Henderson-Smart and Davisand updated as current in 2005 (Henderson-Smart et al. (1988) Carotid sinus hypersensi-tivity in patients with unexplained syncope: clinical, electro-physiologic, and long-term follow-up observations

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